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CART療法における合併症に関してもintroductionに挙げております. 非血液内科専門医でも今後, 日常臨床で遭遇しうるケースになるかと思います. そのような勉強もかねて, 確認いただけると幸いです.
当院の科内抄読会で扱ったスライドになります. NEJMに掲載されたSLEを含めたCAR T療法 (CD19)を施行した患者の長期フォローの転帰を報告した論文になります.
Müller F, Taubmann J, Bucci L et al. CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up. N Engl J Med. 2024 Feb 22;390(8):687-700. PMID38381673.
CAR-T療法
Akatsuka Y, CAR-T細胞療法の基礎と今後の臨床展開, Japanese Journal of Transfusion and Cell Therapy, Vol. 65. No. 6 65(6) : 851―857, 2019
von Büdingen HC, Palanichamy A, Lehmann-Horn K et al. Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets. Eur Neurol. 2015;73(3-4):238-246. PMID 25824054
大西 康, CAR-T細胞療法の基礎知識, 日本造血・免疫細胞療法学会雑誌, 2023, 12 巻, 3 号, p. 148-156
Antaa slide “最近話題のCAR-T療法ってなあに?
Mackensen A, Müller F, Mougiakakos D, et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2022 Oct;28(10):2124-2132. PMID 36109639
Kansal R, Richardson N, Neeli I, et al. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. Sci Transl Med. 2019 Mar 6;11(482):eaav1648. PMID 30842314
Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975 Feb 20;292(8):403-7. doi: 10.1056/NEJM197502202920807. PMID: 1089199.
van den Hoogen F, Khanna D, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum. 2013 Nov;65(11):2737-47. PMID24122180
Aggarwal R, Rider LG, Ruperto N, et al. 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Arthritis Rheumatol. 2017 May;69(5):898-910. PMID28382787
Rider LG, Koziol D, Giannini EH, et al. Validation of manual muscle testing and a subset of eight muscles for adult and juvenile idiopathic inflammatory myopathies. Arthritis Care Res (Hoboken). 2010 Apr;62(4):465-72. PMID20391500
Valentini G, Iudici M, Walker UA, et al. The European Scleroderma Trials and Research group (EUSTAR) task force for the development of revised activity criteria for systemic sclerosis: derivation and validation of a preliminarily revised EUSTAR activity index. Ann Rheum Dis. 2017 Jan;76(1):270-276. PMID: 27621285.
Khanna D, Furst DE, Clements PJ, et al. Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis. J Scleroderma Relat Disord. 2017 Jan-Apr;2(1):11-18. PMID: 28516167.
日本皮膚科学会 全身性強皮症 診断基準・重症度分類・診療ガイドライン委員会 日本皮膚科学会ガイドライン「全身性強皮症 診断基準・重症度分類・診療ガイドライン」
Lee DW, Santomasso BD, Locke FL, et al. ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells. Biol Blood Marrow Transplant. 2019 Apr;25(4):625-638. PMID: 30592986.
Mougiakakos D, Krönke G, Völkl S, et al. CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus. N Engl J Med. 2021 Aug 5;385(6):567-569. PMID: 34347960.
Müller F, Boeltz S, Knitza J, et al. CD19-targeted CAR T cells in refractory antisynthetase syndrome. Lancet. 2023 Mar 11;401(10379):815-818. PMID: 36930673.
Taubmann J, Knitza J, Müller F, et al. Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies. Rheumatology (Oxford). 2024 Jan 4;63(1):e12-e14. PMID: 37432378
Bergmann C, Müller F, Distler JHW, et al. Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells. Ann Rheum Dis. 2023 Aug;82(8):1117-1120. PMID: 37147112.
BD Biosciences https://www.bdbiosciences.com/ja-jp/learn/research/immunology/b-cells#Overview
Abcam https://www.abcam.co.jp/primary-antibodies/b-cells-basic-immunophenotyping-2
Kubo S, Nakayamada S, Yoshikawa M, et al. Peripheral Immunophenotyping Identifies Three Subgroups Based on T Cell Heterogeneity in Lupus Patients. Arthritis Rheumatol. 2017 Oct;69(10):2029-2037. PMID: 28605137.
Cambridge G, Leandro MJ, Teodorescu M et al. B cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles. Arthritis Rheum. 2006 Nov;54(11):3612-22 PMID: 17075806.
Illei GG, Yarboro CH, Kuroiwa T, et al. Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. Rheumatology (Oxford). 2007 Jun;46(6):952-6. PMID: 17317716.
Adams EM, Pucino F, Yarboro C, et al. A pilot study: use of fludarabine for refractory dermatomyositis and polymyositis, and examination of endpoint measures. J Rheumatol. 1999 Feb;26(2):352-60. PMID: 9972969.
Samur MK, Fulciniti M, Aktas Samur A, et al. Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma. Nat Commun. 2021 Feb 8;12(1):868. PMID: 33558511
Hamieh M, Dobrin A, Cabriolu A et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. 2019 Apr;568(7750):112-116. PMID: 30918399.
https://www.yodosha.co.jp/jikkenigaku/book/9784758125734/2948.html
Wang W, He S, Zhang W, et al. BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trial. Ann Rheum Dis. 2024 May 30:ard-2024-225785. PMID: 38777376.
Zhang W, Feng J, Cinquina A et al. Treatment of Systemic Lupus Erythematosus using BCMA-CD19 Compound CAR. Stem Cell Rev Rep. 2021 Dec;17(6):2120-2123. PMID: 34458965.
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