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59 yo female A case of bilateral nosebleeds while being treated for pneumonia
順天堂大学医学部総合診療科学講座/マヒドン大学熱帯医学部・医学部
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概要
59 yo female A case of bilateral nosebleeds while being treated for pneumonia
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医学生／研修医／専攻医／専門医
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59歳女性の鼻出血の症例と病歴
#1.
59 yo female A case of bilateral nosebleeds while being treated for pneumonia Hirotake Mori h.mori.oa@juntendo.ac.jp Department of General Medicine Faculty of Medicine, Juntendo University
#2.
Case: 59yo female Chief complaints: fever, cough Present Medical History: The patient presented to the hospital with a fever and persistent productive cough that began 4 days prior. Childhood history was significant for recurrent bilateral nosebleeds. A diagnosis of allergic rhinitis had been previously made by ENT.
#3.
Past Medical History: gastric ulcers, nosebleeds Medication: - Nizatidine (150mg) 2 tablets PO bid (after meals, morning, evening) - Fexofenadine (60mg) 2 tablets PO bid (after meals, morning, evening) Lifestyle: social drinker, non-smoker Allergy: none Family History: Mother: surgical resection of the lungs for pulmonary AVM Eldest daughter: x-ray of the chest revealed abnormal lung shadows during a routine health maintenance visit.
身体検査と検査結果の概要
#4.
Physical Examination Height: 162cm Weight: 39kg Vital signs: BP 138/58mmHg, HR 97bpm, RR 20/min, SpO2 91%, BT 37.9℃ Face: ulcerations in the perioral region Chest: auscultation of the posterior chest revealed coarse crackles at the left lower lung field. Abdomen, extremities: no abnormalities
#5.
Laboratory Test Results ＜CBC＞ WBC ＜Metabolic Panel＞ 4.7 ×103/mL Na 134 mmol/L Nt 93.5 ％ K 3.6 mmol/L Ly 4.7 ％ Cl 97 mmol/L Hb 14.6 g/dL AST 56 U/L Ht 43.3 % ALT 25 U/L MCV 90.4 fL T-Bi 1.4 mg/dL MCH 30.6 pg BUN 55 mg/dL Plt 182 ×103/μL Cr CRP ＜Urine Rapid Antigen Test＞ Urine legionella （－） Urine pneumococcus （＋） *unable to obtain sputum sample* 1.23 mg/dL 42.03 mg/dL WBC left shift, abnormal LFT / kidney function, and high CRP
#6.
X-ray of the Chest
胸部CTスキャンと入院経過
#7.
CT Scan of the Chest CT scan revealed hyperdense infiltrate in the left lung accompanied by air bronchograms. Diagnosis was made for pneumococcal pneumonia. The patient was hospitalized, and treatment was initiated.
#8.
Course of Hospitalization 38 37.5 37 36.5 36 35.5 1 2 3 4 5 6 7 8 9 10 11 12 13 CTRX 2g/day AZM 500mg/day O2 admin. 1L CRP (mg/dl) 42 1L 39 Discontinued 6 Pneumococcal pneumonia: breathing function, values of LFT / kidney function improved within a few days.
#9.
Course of Hospitalization Bilateral nosebleeds 38 37.5 37 36.5 36 Ulcerations of the perioral region, nostril, soft palate, pharynx 35.5 1 2 3 4 5 6 7 CTRX 2g/day AZM 500mg/day - Ulceration was seen in the perioral region, nasal cavity, soft palate, and pharynx. - Persistent bilateral nosebleeds 8 9 10 11 12 13
入院中の鼻出血の特徴と評価
#10.
Course of Hospitalization Bilateral nosebleeds 38 37.5 37 36.5 36 Ulcerations of the perioral region, nostril, soft palate, pharynx 35.5 1 2 3 4 5 6 7 8 CTRX 2g/day AZM 500mg/day HSV Infection Acyclovir IV → Valacyclovir PO １）Pneumococcal pneumonia ２）HSV infection ３）Bilateral nosebleeds?? 9 10 11 12 13
#11.
Characteristics of the Nosebleed Bilateral slow, oozing bleeding intermittent course postnasal drip dried blood clot → evaluation of nasal cavity proved difficult nasal obstruction → dryness, pain in the oral cavity → loss of appetite is exacerbated. The patient’s words verbatim: “The nosebleed is the same as before…” Due to the unusual characteristics of the nosebleed, consultation with the ENT dept. was indicated.
#12.
Telangiectasia in the nasal cavity and tongue Hereditary Hemorrhagic Telangiectasia (HHT) is suspected.
遺伝性出血性毛細血管拡張症（HHT）の診断基準
#13.
Course of Hospitalization Bilateral nosebleeds 38 37.5 37 36.5 36 Ulcerations of the perioral region, nostril, soft palate, pharynx 35.5 1 2 3 4 5 6 7 8 9 10 11 12 13 CTRX 2g/day AZM 500mg/day HSV Infection Acyclovir IV → Valacyclovir PO - nasal irrigation was performed by ENT. １）Pneumococcal pneumonia - Vaseline was applied for moisturization, barrier protection. ２）HSV infection - pt was discharged on day 12 after ３）HHT resolution of the nosebleeds
#14.
Hereditary Hemorrhagic Telangiectasia (HHT) Diagnostic Criteria: ① spontaneous, recurrent epistaxis ② mucocutaneous telangiectasias characteristic locations: lip, oral cavity, nose, digits others: sclera, ear ③ presence of arteriovenous malformation (AVM) in the: lung, brain, liver, spinal cord, digestive tract ④ patient is a first degree relative of a family member with HHT. More than 3 criteria → definitive diagnosis More than 2 criteria → suspected diagnosis
家族歴と関連するAVMの評価
#15.
no remarkable AVM was revealed
#16.
Eldest daughter 34yo female The patient’s daughter presented to the outpatient for further investigation of the abnormal lung shadows that was revealed during a previous health maintenance visit. The daughter was referred to the university hospital for evaluation of the pulmonary AVM, genetic testing, and treatment.
#17.
Hereditary Hemorrhagic Telangiectasia (HHT) Diagnostic Criteria: ① spontaneous, recurrent epistaxis ② mucocutaneous telangiectasias characteristic locations: lip, oral cavity, nose, digits others: sclera, ear ③ presence of arteriovenous malformation (AVM) in the: lung, brain, liver, spinal cord, digestive tract ④ patient is a first degree relative of a family member with HHT. More than 3 criteria → definitive diagnosis More than 2 criteria → suspected diagnosis ①②④ → 3 criteria were satisfied for a definitive diagnosis.
HHTの臨床的特徴と遺伝的要因
#18.
＜Considerations＞ Hereditary Hemorrhagic Telangiectasia (HHT) Prevalence 1:5000～1:8000 Otolaryngol Clin N Am 51 (2018) 237–254 Many patients with the disorder remain undiagnosed. Although HHT affects multiple organ systems, epistaxis is the most common presenting symptom, and patients are usually referred to ENT. As such, many internal medicine specialists do not get the opportunity to encounter this disorder in clinical practice.
#19.
Hereditary Hemorrhagic Telangiectasia (HHT) Autosomal Dominant Inheritance Type 1 Gene ENG (Endogolin) Ch Freq（％） ９ 2 ACVRL1 １２ 61 37 １８ 2 (activin A receptor type II-like 1 gene) MADH4 3,4 5q and 7p These genes code for membrane proteins involved in the TGF-β signal transduction pathway found in epithelial cells. Otolaryngol Clin N Am 51 (2018) 237–254
#20.
Hereditary Hemorrhagic Telangiectasia (HHT) Diagnostic Criteria: Curaçao Criteria for HHT Criteria 1. 2. 3. 4. epistaxis telangiectasia AVM family history Description - spontaneous, recurrent - characteristic region: perioral region, oral cavity, digits, nose - organ involvement: digestive tract, lung, liver, brain, spinal cord History of HHT within first degree relatives Definitive: 3 or more findings Suspected: 2 findings HHT unlikely: 1 or no findings The diagnostic criteria are closely linked to the genetic profile of the disorder. J Med Genet published online June 23, 2009.
HHTの治療法と予防策
#21.
Clinical signs, Disease Freq.（％） Nosebleeds 95 GI bleeds 20 AVM Lung 50 Liver 30 Central nervous system 10
#22.
Int J Womens Health. 2017; 9: 373–378.
#23.
Otolaryngol Clin N Am 51 (2018) 237–254
#24.
Hereditary Hemorrhagic Telangiectasia (HHT) Treatment, Preventive Measures Epistaxis moisturization (barrier protection), coagulation, surgical intervention → invasive procedures have the risk of worsening epistaxis and/or rupture of the nasal septum. Lung Arteriovenous Malformation Risk of heart failure Risk of brain abscess / infarct that is caused by the shunt → consider minimally invasive catheter procedures, surgical intervention, prophylactic antibiotics → scuba diving must be avoided. J Med Genet published online June 23, 2009.
早期発見の重要性と結論
#25.
The Significance of Early Detection / Diagnosis Eldest daughter 33yo female When the daughter was 25yo, she reported dizziness and numbness after scuba diving in Phuket island, Thailand. She was admitted to a local facility, but no diagnosis was made in Thailand. Recent investigations revealed an old (previous) cerebellar infarct.
#26.